Cellular Plasticity in Cancer: Adaptive Mechanisms Driving Progression and Evasion

Roopak, Aggarwal and Natasha, Singh and Jyoti, Mishra and Pinki, Pandey and Himanshu, Joshi and Sanjay, Kannaujia (2024) Cellular Plasticity in Cancer: Adaptive Mechanisms Driving Progression and Evasion. In: Achievements and Challenges of Medicine and Medical Science Vol. 8. BP International, pp. 15-27. ISBN 978-93-48859-06-8

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Abstract

Background: Cellular plasticity refers to the ability of cells to adapt their characteristics, including phenotype and function, in response to environmental changes. This ability is vital for normal physiological processes, such as embryonic development, tissue regeneration, and immune responses. However, cellular plasticity plays a pathologically significant role in cancer, where it complicates treatment efforts and contributes to disease progression.

Objective: The objective of the study is to explore the role of cellular plasticity in cancer progression, with a particular focus on the plasticity of the epithelial-to-mesenchymal transition (EMT) and its impact on therapeutic strategies.

Methods: The study synthesizes current research on the mechanisms of cellular plasticity in cancer, including the genetic mutations and epigenetic alterations that lead to disrupted cellular functions. Special attention is given to the challenges posed by the plastic nature of EMT in developing effective cancer therapies.

Results: Cancer progression involves a multistep process characterized by the accumulation of genetic and epigenetic changes. These changes drive cellular plasticity, facilitating the adaptation of cancer cells to diverse environments and contributing to therapy resistance. Traditional cancer treatments often target specific states associated with epithelial or mesenchymal phenotypes, but the dynamic plasticity of cancer cells undermines the effectiveness of such approaches.

Conclusion: The plasticity of cancer cells, particularly through EMT, presents significant obstacles to conventional cancer therapies. Continued research is essential to develop innovative treatment strategies that account for cellular plasticity, with the ultimate goal of improving survival rates and the quality of life for cancer patients.

Item Type: Book Section
Subjects: Digital Open Archives > Medical Science
Depositing User: Unnamed user with email support@digiopenarchives.com
Date Deposited: 10 Jan 2025 06:03
Last Modified: 08 Apr 2025 12:56
URI: http://doc.send2pub.com/id/eprint/1919

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